Synthesis of a Cyclic Melanotropic Peptide Exhibiting Both Melanin-Concentrating and -Dispersing Activities
- 8 June 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 224 (4653) , 1111-1113
- https://doi.org/10.1126/science.6609433
Abstract
A putative melanin-concentrating hormone was synthesized. This peptide, H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH , stimulates melanin granule aggregation within teleost melanocytes at nanomolar concentrations as does the natural purified teleost pituitary preparation. In addition, this peptide stimulates melanin granule dispersion within melanocytes of frogs and lizards. The peptide has about one six-hundredth of the activity of alpha-melanocyte-stimulating hormone on frog and lizard melanocytes and is a full agonist.This publication has 12 references indexed in Scilit:
- Differentiation of the structural features of melanotropins important for biological potency and prolonged activity in vitroInternational Journal of Peptide and Protein Research, 1983
- Characterization of melanin-concentrating hormone in chum salmon pituitariesNature, 1983
- αMelanocyte Stimulating Hormone: Chemical Nature and Mechanism of ActionAmerican Zoologist, 1983
- Comparative biological activities of highly potent active-site analogs of .alpha.-melanotropinJournal of Medicinal Chemistry, 1982
- The bio‐organic chemistry of α‐melanotropinMedicinal Research Reviews, 1982
- Synthesis and structure-function studies of melanocyte stimulating hormone analogs modified in the 2 and 4(7) positions: comparison of activities on frog skin melanophores and melanoma adenylate cyclaseJournal of Medicinal Chemistry, 1980
- The teleost melanin-concentrating hormone—A pituitary hormone of hypothalamic originGeneral and Comparative Endocrinology, 1979
- Melanophore-Contracting Hormone (MCH) of Possible Hypothalamic Origin in the Catfish, ParasilurusScience, 1955
- IN VITROBIOASSAY FOR THE MELANOCYTE STIMULATING HORMONE1Endocrinology, 1954
- The pigmentary effector system. VI. The dual character of endocrine co-ordination in amphibian colour changeProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1931