Mathematical Correlation Between ADP‐Induced Platelet Aggregation and Subsequent Disaggregation

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Abstract
The turbidimetrically obtained curves of ADP‐induced platelet aggregation in plateletrich plasma at 37° C. can be mathematically characterized by a logarithmically normal frequency distribution suggesting that the phase of aggregation and the subsequent disaggregation are governed by the same mechanism. Every curve can be described with reference to three parameters, viz.: the maximum change in optical density (ODmax), the time at which this occurs (tmax and the standard deviation of the logarithms of the time variable (s̀).Aggregation curves of 21 normal subjects, 17 uraemic patients and 11 patients with Von Willebrand̂s disease were studied.Parameter ODmax although dependent on the platelet concentration was significantly diminished in a proportion of the uraemic patients.Neither group of patients differed significantly from the normals in parameter tmax. A significant number of uraemic patients and Von Willebrand patients showed lower s̀ values than those found in normal subjects. The abnormality thus indicated entails abnormally rapid disaggregation.The new parameter (s̀) proved to be a better reproducible and more sensitive measure of the aggregation process than the hitherto usual parameters ODmax and tmax.