Incorporation of Tritium from Succinate-2,3-H.3 into Long Chain Fatty Acids by Aortic Mitochondria.

Publisher Website
Google Scholar
Abstract
Summary The mechanism of succinate stimulation of fatty acid synthesis by aortic mitochondria was studied. Tritium, but not carbon, from succinate labeled in positions 2- and 3- is incorporated into long-chain fatty acids in this system. The relative incorporation of tritium in various fatty acids is similar to that of C14 from acetate. Succinate can, therefore, provide protons for the reductive steps. We believe this is a demonstration of energy-requiring reversal of electron flow participating in a synthetic process and another way in which Krebs Cycle acids can influence fatty acid synthesis.

This publication has 0 references indexed in Scilit: