SEQUENTIAL MORPHOLOGICAL AND QUANTITATIVE CHANGES IN BLOOD AND BONE-MARROW NEUTROPHILS IN DOGS WITH ACUTE-INFLAMMATION

  • 1 January 1985
    • journal article
    • research article
    • Vol. 49  (3) , 291-297
Abstract
Blood and bone marrow morphology were studied sequentially in dogs during experimental inflammation induced by i.m. injection of turpentine. Depletion of the bone marrow storage pool of mature neutrophils and an increase in mitotic activity and number of early granulocyte precursors were evident within 24 h. During the next 3 days, intense granulocytic hyperplasia resulted in replenishment of the bone marrow storage pool. Neutrophils with foamy vacuolation and increased basophilia of the cytoplasm (toxic neutrophils) were present in the blood by 8 h postinjection. The number of toxic neutrophils paralleled the intensity of clinical signs and changes in rectal temperature but not the number of band neutrophils. Changes in number of toxic neutrophils in sequential leukograms can be a prognostic indicator in dogs with severe inflammation.