Comparison of tetracycline and minocycline in the treatment of non-gonococcal urethritis.

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Abstract
The activity of tetracycline hydrochloride and minocycline hydrochloride was compared against 12 strains of Chlamydia trachomatis and Ureaplasma urealyticum; minocycline was more active in vitro against both organisms. A group of 145 men with non-gonococcal urethritis was treated for 1 wk with either tetracycline hydrochloride 500 mg 6 hourly or minocycline 50 mg twice daily. The clinical results obtained were similar: 61 of 77 (79%) men treated with tetracyline and 53 of 68 (78%) men treated with minocycline were free from urethritis 1-2 wk after completing treatment. Both antibiotics were clinically effective against C. trachomatis, but activity against U. urealyticum was less consistent. Side effects were noted in 14 (18%) men treated with tetracycline and 8 (12%) men treated with minocycline; they were predominantly gastrointestinal.