Endocrine Cells in Oxyntic Mucosa of a Dog 5 Years after Pancreatectomy

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Abstract
Immunofluorescence shows that the oxyntic mucosa of a dog depancreatized for 5 years and having a poorly-controlled diabetes has more glucagon- and somatostatin-containing cells than the mucosa of a control dog. At the ultrastructural level, 4 endocrine cell types are identified : A-, A-like, D- and enterochromaffin-like (ECL) cells, with increased numbers of A-, A-like and D-cells in gastric glands of the depancreatized dog, together with a higher concentration of immunoreactive glucagon in the gastric mucosa. The increase in A-, A-like and D-cells is compatible with : a) a change induced by the diabetic state itself; b) a hyperplasia secondary to the loss of corresponding pancreatic cells. At any rate, the fact that A-, A-like and D-cells increase parallely may indicate that these three cell types are functionally related one with another. 1 Supported by the Swiss National Science Foundation (grants nr 3.553.75, 3.120.77), by U.S. P.H.S. (grant nr EY 00300), and by a MRC (Canada) grant, nr. MT-2196