GENETIC-CONTROL OF INVITRO NATURAL CELL-MEDIATED ACTIVITY AGAINST SALMONELLA-TYPHIMURIUM BY INTESTINAL AND SPLENIC LYMPHOID-CELLS IN MICE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 56  (3) , 531-536
Abstract
In vitro natural antibacterial activity against S. typhimurium by lymphocytes from Peyer''s patches and spleens was assessed in several mouse strains. C3H/HeN and CBA/J mice, which are resistant to S. typhimurium infections, showed a natural antibacterial activity significantly higher than BALB/c, C57BL/10, C57BL/6 and C3H/HeJ mice, i.e., strains susceptible to the in vivo bacterial infection. In these susceptible strains and also in A/J mice, a significantly higher natural activity was observed in females compared to males. The sex control of natural antibacterial activity was further stressed by the fact that orchidectomy could induce a strong activity in low responder C57BL/10 male mice. With the exception of Beige mice, a low natural killer (NK) strain also with no natural activity against S. typhimurium in both sexes, the genetic distribution of natural antibacterial activity was extremely different from that of the NK activity. Thus, the difference between natural antibacterial activity and NK cytotoxicity was further stressed. A possible link, although with some exceptions, was established between in vivo susceptibility to S. typhimurium infections and in vitro natural activity against these bacteria.