Chemistry of 6H-pyrido[4,3-b]carbazoles. Part 12. Synthesis of potential bisintercalating drugs bearing two ellipticine units
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 11,p. 2933-2943
- https://doi.org/10.1039/p19880002933
Abstract
A number of bisellipticines have been synthesized in an attempt to increase the potency of the parent tetracycles as anti-cancer drugs through bis-intercalation into the same strand of DNA. The compounds described are structures in which two pyrido[4,3-b]carbazole units are joined at C-5 by an alkyl chain and two amide functions. The preparation of a number of new ellipticine ‘monomers’ is reported, as well as a synthesis of the alkaloid 5-formyl-11-methyl-6H-pyrido[4,3-b]carbazole. A novel oxidative coupling reaction of ellipticines has also been discovered.This publication has 8 references indexed in Scilit:
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