Selective detection of fluorophore layers in turbid media: the role of fiber-optic probe design
- 15 January 2003
- journal article
- Published by Optica Publishing Group in Optics Letters
- Vol. 28 (2) , 120-122
- https://doi.org/10.1364/ol.28.000120
Abstract
Experimental verification of the ability to alter the sensitivity to fluorophore layers in turbid media by varying illumination-collection geometry is presented. Fiber-optic probes and two-layer, fluorophore-doped, turbid phantoms are used to elucidate the roles of spot size, illumination–collection fiber separation, and probe–sample spacing. Variations in single- and multiple-fiber probe design parameters produce significant changes in the relative sensitivity to sample layers in a manner that agrees with prior computational studies.Keywords
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