Effects of Cyanamide and Ethanol on Bleeding Weight and Blood Acetaldehyde in Mice and Rats

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Abstract
Cyanamide alone did not increase the blood acetaldehyde but significantly reduced the bleeding weight at the largest dose. Ethanol alone increased the blood acetaldehyde to a mean level of 0.39 mg/100 ml at the highest dose but did not significantly reduce the bleeding weight. Cyanamide (20 mg/kg) followed by ethanol increased blood acetaldehyde to a maximum of 2.5 mg/100 ml but did not significantly lower the bleeding weight. A larger dose of cyanamide (125 mg/kg) followed by ethanol induced even greater rises in blood acetaldehyde, and decreases in bleeding weight which were significant at blood acetaldehyde levels of 1.3 mg/100 ml and up. Cyanamide alters the reaction of animals to ethanol not only by increasing the concentration of acetaldehyde in the blood but by altering the vascular reaction to acetaldehyde or ethanol.