The Intracellular Fate of Histoplasma capsulatum in Human Macrophages Is Unaffected by Recombinant Human Interferon-

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Abstract
Human a1veoloar, peritoneal, and cultured macrophages were exposed in vitro to human recombinant interferon-γ (rHuIFN-γ) and were tested for their ability to inhibit intracellular replication of yeast-phase Histoplasma capsulatum. Exposure at various concentrations, and for different time periods, failed to activate the macrophages to inhibit multiplication of intracellular yeast. Macrophages were, however, activated by rHuIFN-γ as shown by their ability to inhibit intracellular replication of Trypanosoma cruzi and by their enhanced production of superoxide when stimulated by phorbol myristate acetate. These data indicate that rHuIFN-γ by itself does not activate human macrophages to inhibit intracellular proliferation of yeast-phase H. capsulatum.