SEQUENCES OF INTEREST: Human Placental 17β-Hydroxysteroid Dehydrogenase is Homologous to NodG Protein ofRhizobium meliloti
- 1 May 1989
- journal article
- research article
- Published by The Endocrine Society in Molecular Endocrinology
- Vol. 3 (5) , 881-884
- https://doi.org/10.1210/mend-3-5-881
Abstract
The amino acid sequence of human placental 17.beta.-hydroxysteroid dehydrogenase (17.beta.-OH-steroid dehydrogenase) was found to be similar to that of the NodG protein of R. meliloti. The computer-based comparison score is 11.5 SD higher than that obtained with 2500 comparisons of randomized sequences of these proteins. The probability of getting such a score by chance is 6 .times. 10-31. 17.beta.-OH-steroid dehydrogenase is also similar to Klebsiella aerogenes ribitol dehydrogenase and Escherichia coli glucitol-6-phosphate dehydrogenase. We propose that the steroid recognition site on 17.beta.-OH-steroid dehydrogenase evolved from an ancestral recognition site for polyols such as ribitol and glucitol-6-phosphate.This publication has 15 references indexed in Scilit:
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