Sulfite Induced Anaerobic Degradation of Epinephrine in Lidocaine Hydrochloride Injection
- 1 January 1977
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 3 (1) , 65-72
- https://doi.org/10.3109/03639047709055605
Abstract
The sulfite induced anaerobic degradation of epinephrine in lidocaine hydrochloride injection, U.S.P. was studied, at pH 4.0 and 4.4. The epinephrine concentration was 0.001 per cent. The activation energy parameters were evaluated from arrhenius type plots. DLH was found to be 23.6 and 23.9 kcal mole−1 for pH 4.0 and 4.4 respectively and compared favourably with literature value. Based on these results, shelf life was predicted and changes in U.S.P. monograph are suggested. The anaerobic degradation of epinephrine in aqueous solution over the 3.63–5.00 pH range was reported earlier (1) as a preliminary to stability studies on products containing epinephrine. The degradation of epinephrine was induced by sodium metabisulfite. The purpose of this investigation was to study the sulfite induced anaerobic degradation of epinephrine in Lidocsine Hydrochloride Injection, U.S.P.This publication has 2 references indexed in Scilit:
- Kinetics of Sulfite‐Induced Anaerobic Degradation of EpinephrineJournal of Pharmaceutical Sciences, 1975
- A Kinetic Study of Acid-Catalyzed Racemization of Epinephrine * *School of Pharmacy, University of Wisconsin, Madison.Journal of the American Pharmaceutical Association (Scientific ed.), 1958