Aminoglycoside antibiotics. XII. Effect of N-alkylation in kanamycin antibiotics.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (7) , 675-680
- https://doi.org/10.7164/antibiotics.31.675
Abstract
Four N-ethyl derivatives of kanamycin A and 5 N-ethyl derivatives of kanamycin B were synthesized. The antimicrobial activity of N-ethyl kanamycin derivatives was determined against aminoglycoside-sensitive and resistant organisms. The structure-activity relationship of these compounds is discussed with reference to the activity of N-acyl kanamycin derivatives.This publication has 0 references indexed in Scilit: