Clinical Studies with LSD-25 and Two Substances Related to Serotonin
- 1 January 1960
- journal article
- Published by Royal College of Psychiatrists in Journal of Mental Science
- Vol. 106 (442) , 301-308
- https://doi.org/10.1192/bjp.106.442.301
Abstract
In 1953, Twarog and Page (1) demonstrated that 5-hydroxytryptamine (serotonin) is present in relatively high concentrations in the brain. At about the same time Gaddum (2) and Woolley and Shaw (3) observed that LSD is a highly potent serotonin antagonist in such tissues as rat uterus and hypothesized that the hallucinogenic effect of LSD might be due to interference in the action of serotonin.Keywords
This publication has 10 references indexed in Scilit:
- CLINICAL EVALUATION OF BAS (BENZYL ANALOG OF SEROTONIN)Journal of Nervous & Mental Disease, 1958
- THE EFFECTS OF TWO ANTISEROTONIN SUBSTANCES (BAS AND BAB) AND OF BUFOTENIN ON THE SPONTANEOUS ELECTRIC ACTIVITY OF THE BRAIN1Journal of Nervous & Mental Disease, 1958
- Studies with the Serotonin Precursor, 5-Hydroxytryptophan, in Experimental Animals and ManJournal of Clinical Investigation, 1957
- Serotonin and AntiserotoninsCirculation, 1957
- Effect of 5-Hydroxytryptophane Upon Electroencephalogram in Hepatic Coma.Experimental Biology and Medicine, 1957
- A CONCEPT FOR A ROLE OF SEROTONIN AND NOREPINEPHRINE AS CHEMICAL MEDIATORS IN THE BRAINAnnals of the New York Academy of Sciences, 1957
- SEROTONIN‐LSD INTERACTIONSAnnals of the New York Academy of Sciences, 1957
- EVIDENCE FOR THE PARTICIPATION OF SEROTONIN IN MENTAL PROCESSESAnnals of the New York Academy of Sciences, 1957
- Lysergic Acid Diethylamide in Patients with Excess SerotoninArchives of Neurology & Psychiatry, 1956
- Serotonin Content of Some Mammalian Tissues and Urine and a Method for Its DeterminationAmerican Journal of Physiology-Legacy Content, 1953