QUANTITATIVE EVALUATION OF CARDIOVASCULARSTIMULANT DRUGS IN BARBITURATE DEPRESSION OF THE HEART OF THE DOG

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Abstract
35 mongrel dogs weighing approx. 10 kg. were anesthetized with 30 mg./kg. of pentobarbital-Na intraven. An endotracheal catheter was employed to facilitate artificial respiration with a Bird piston-type respirator. The right jugular vein was cannulated for admn. of cardiovascular drugs. After stabilization pentobarbital-Na was administered at 5 mg./kg./min. until death, by a mechanical injector connected to a polyethylene catheter in the left femoral vein. The cannulated left common carotid artery was connected to a Statham pressure transducer which recorded through a Brush strain analyzer and a Brush oscillograph. Ouabain, 0.25-0.5 cat units/kg. was given in a 20 min. interval prior to pentobarbital-Na infusion. When respiratory arrest occurred, artificial respiration was instituted at the rate of 15 inflations per min. When cardiac arrest appeared imminent, one of the sympathomimetic amines was injd. intraven. and repeated when need indicated, by pulse pressure recording. The initial dose of ephedrine was 1 mg./kg., and aranthol (methylamino-iso-octanol) 10 mg./kg. The dose of pentobarbital Na to produce cardiac arrest was 2.9 [plus or minus] 0.8 times the dose to produce respiratory arrest. This was elevated to 4.0 [plus or minus] 0.9 with ouabain. Ephedrine elevated the cardiac arrest dosage to 9.5 [plus or minus] 1.4 times and aranthol to 9.7 [plus or minus] 2.3 times the dosage of pentobarbital Na required to produce respiratory arrest.

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