The Biosynthesis of Collagen

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Abstract
Micro-Heterogeneity in the Biosynthesis of CollagenDetailed analyses of the structure of the polypeptide chains of collagen has revealed a "micro-heterogeneity" of the amino acid sequences. Sequencing of the first 50 amino acid residues from the NH2-terminal end of the α1 chain of rat skin and tendon collagen indicated that although there were several triplets of the structure -Gly-X-Hypro-, an appreciable fraction of the amino acid in the third position of such triplets was Pro rather than Hypro.109,110 A similar situation has been found for Hypro in most109,110, 139 , 140 but not all141 , 142 of the triplets that have been . . .