Hypophosphatemic Osteomalacia with Hyperglycinuria

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Abstract
In 1956 Dent and Harris (1) described four patients with hypophosphatemic osteomalacia (phosphate diabetes; vitamin D refractory osteomalacia), who differed from those with the hereditary form of the disease by onset of symptoms during adolescence or adult life, negative family history, and evidence of increased urinary excretion of glycine (2). We have recently studied a patient who presents a further example of this syndrome. The presence of hyperglycinuria was demonstrated by high-voltage chromatography (3) and quantitated by microbiological assay (4). Treatment with neutral phosphate and moderate doses of calciferol produced a gratifying clinical improvement. A 24-year-old white female
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