The co-chaperone BAG3 regulates Herpes Simplex Virus replication
- 30 December 2008
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 105 (52) , 20912-20917
- https://doi.org/10.1073/pnas.0810656105
Abstract
Viruses as obligate intracellular parasites use host cell proteins to ensure efficient replication and spread. Cellular proteins are required for several stages of a virus life cycle. Here, we identify BAG3, a co-chaperone, as a regulator of herpes virus immediate early gene expression. We report that a herpes simplex virus lacking the gene encoding a potent transcriptional activator, ICP0, is compromised for replication in cells silenced for BAG3 in a multiplicity of infection-dependent manner. We also show a requirement for BAG3 to augment virus gene expression and demonstrate that the co-chaperone acts independently of promyelocytic leukemia to increase herpes simplex virus replication.Keywords
This publication has 42 references indexed in Scilit:
- Nuclear Import of the Varicella-Zoster Virus Latency-Associated Protein ORF63 in Primary Neurons Requires Expression of the Lytic Protein ORF61 and Occurs in a Proteasome-Dependent MannerJournal of Virology, 2008
- Oligomerization of ICP4 and Rearrangement of Heat Shock Proteins May Be Important for Herpes Simplex Virus Type 1 Prereplicative Site FormationJournal of Virology, 2008
- Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100Journal of Virology, 2008
- Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST–REST complexProceedings of the National Academy of Sciences, 2007
- Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 systemNucleic Acids Research, 2007
- BAG3, a Host Cochaperone, Facilitates Varicella-Zoster Virus ReplicationJournal of Virology, 2007
- Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand virusesVirology, 2007
- Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90The EMBO Journal, 2006
- Evidence for a Role of the Cellular ND10 Protein PML in Mediating Intrinsic Immunity against Human Cytomegalovirus InfectionsJournal of Virology, 2006
- PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0Journal of Virology, 2006