Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.
Open Access
- 1 June 1995
- journal article
- case report
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 58 (6) , 742-744
- https://doi.org/10.1136/jnnp.58.6.742
Abstract
Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS.Keywords
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