Time-Temperature Conversions in Biological Applications of Hyperthermia

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Abstract
The heating of cells or tissues generally involves a temperature transient during which the temperature of the heated object rises from an initial to a final level with biological effects occurring during this interval. These effects can be estimated by using data on isobiological effects obtained both in vitro and in vivo. The method has limitations in that it cannot be applied under conditions where thermotolerance develops or step-down heating occurs. Several examples from in vivo using a mouse intestine, normal mouse foot, and a mouse foot with an implanted tumor and in vitro [using Chinese hamster ovary cells] applications serve to illustrate this method as a practical tool in hyperthermia research.

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