PHASE AND ELECTRON MICROSCOPIC STUDIES OF EXPERIMENTAL DEMYELIXATION

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Abstract
Phase and electron microscopic study of normal guinea pig sciatic nerves reveals numerous variations in the myelin sheath contour. For the most part, these variations consist of infoldings into axoplasm or protrusions into Schwann cell cytoplasm and can be seen as isolated myelin ovoids in a single plane of section. They are most numerous in the juxtanodal region of the largest fibers and are of particular importance to neuropathologists because of their resemblance to myelin forms seen with the light microscope in early demyelinative lesions. Several other features of peripheral nerve ultrastructure are briefly described.