Preferential Transmission of Diabetic Alleles within the HLA Gene Complex
- 20 November 1986
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 315 (21) , 1314-1318
- https://doi.org/10.1056/nejm198611203152103
Abstract
Several studies suggest a higher incidence of insulin-dependent diabetes mellitus (IDDM) among the offspring of men with the disease than among those of female diabetics. Differential transmission by the father of genes that predispose to diabetes may explain this phenomenon. To test this hypothesis, we examined parent-to-offspring transmission of HLA haplotypes and DR (D-related) alleles in 107 nuclear families in which a child had IDDM.This publication has 37 references indexed in Scilit:
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