Automated Synthesis of a Protected N-Linked Glycoprotein Core Pentasaccharide
- 1 November 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 5 (24) , 4717-4720
- https://doi.org/10.1021/ol035887t
Abstract
Described is the first automated solid-phase synthesis of the core N-linked pentasaccharide, common to all N-linked glycoproteins via stepwise assembly from mono- and disaccharide building blocks. The challenging β-mannosidic linkage was incorporated by the inclusion of a disaccharide trichloroacetimidate. This automated synthesis provides rapid access to an oligosaccharide common to an entire class of glycoconjugates.Keywords
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