Inhibition of Histamine-Stimulated Secretion by Topical Application of Antihistaminics to the Canine Mucosa.

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Abstract
-Antihistaminics usually fail to block histamine-stimulated gastric secretion of HC1 when given parenterally. The gastric receptors for histamine therefore present a puzzling exception to the almost universal blocking action of anti- histaminics on histamine receptors in other sites. Topical application of phenergan, phenergan methosulfate, pyribenzamine, and neoantergan to the mucosa of canine gastric pouches significantly inhibited their acid secretory response to parenterally administered histamine. The local anesthetic nupercaine elicited a similar inhibition. These anti-histaminics and the local anesthetic were also effective in inhibiting acid secretion stimulated by the vagomimetic agent, urecholine. Three possible explanations of the mode of action of the antihistaminics are considered: (1) a specific (antihistaminic) effect, (2) an atropine effect, and (3) a local anesthetic effect. The evidence presently available does not permit any preference among these possibilities.

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