Synthesis and release of doxorubicin from a cephalosporin based prodrug by a β-lactamase-immunoconjugate
- 28 February 1993
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 3 (2) , 323-328
- https://doi.org/10.1016/s0960-894x(01)80902-1
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- Synthesis of novel targeted pro-prodrugs of anthracyclines potentially activated by a monoclonal antibody galactosidase conjugate (part 1)Bioorganic & Medicinal Chemistry Letters, 1992
- Synthesis of acylhydrazido-substituted cephems. Design of cephalosporin-vinca alkaloid prodrugs: substrates for an antibody targeted enzymeThe Journal of Organic Chemistry, 1992
- Monoclonal antibody-.beta.-lactamase conjugates for the activation of a cephalosporin mustard prodrugBioconjugate Chemistry, 1992
- A novel targeted delivery system utilizing a cephalosporin-oncolytic prodrug activated by an antibody β-lactamase conjugate for the treatment of cancerBioorganic & Medicinal Chemistry Letters, 1991
- Activation of prodrugs by targeted enzymesEuropean Journal of Cancer and Clinical Oncology, 1991
- Cephalosporin Nitrogen Mustard Carbamate prodrugs for “ADEPT”.Tetrahedron Letters, 1991
- New hydrazone derivatives of Adriamycin and their immunoconjugates - a correlation between acid stability and cytotoxicityBioconjugate Chemistry, 1991
- The linkage of cytotoxic drugs to monoclonal antibodies for the treatment of cancerBioconjugate Chemistry, 1990
- Recent advances with monoclonal antibody drug targeting for the treatment of human cancerBioconjugate Chemistry, 1990
- A cytotoxic agent can be generated selectively at cancer sitesBritish Journal of Cancer, 1988