Molecular Cloning and Analysis of Full-Length Genome of HIV Type 1 Strains Prevalent in Countries of the Former Soviet Union
- 1 October 2003
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 19 (10) , 933-939
- https://doi.org/10.1089/088922203322493139
Abstract
The HIV-1 epidemic among injecting drug users (IDUs) in countries of the former Soviet Union (FSU) was caused mainly by two HIV-1 variants: subtype A and CRF03-AB. To date only three full-length HIV-1 genomes from the FSU have been sequenced: one subtype A from Byelorussia and two CRF03-AB from Russia. We report the full-length genome cloning and analysis of two more HIV-1 strains from the FSU countries (98UA0116 of subtype A and 98BY10443 of CRF03-AB). Isolate 98UA0116 is the second cloned and sequenced full-length HIV-1 genome of subtype A lineage from the FSU, which may be a novel subsubtype within subtype A. Isolate 98BY10443 is the third full-length HIV-1 genome of CRF03-AB in the world to be cloned and sequenced. Additionally, it is the first CRF03-AB strain discovered in Byelorussia. Cloned genomic sequences of the FSU HIV-1 isolates are being used for the development of a region-specific HIV-1 vaccine.Keywords
This publication has 13 references indexed in Scilit:
- HIV Type 1 Genetic Diversity and Genotypic Drug Susceptibility in the Republic of MoldovaAIDS Research and Human Retroviruses, 2001
- Evidence of Two Distinct Subsubtypes within the HIV-1 Subtype A RadiationAIDS Research and Human Retroviruses, 2001
- An AB Recombinant and Its Parental HIV Type 1 Strains in the Area of the Former Soviet Union: Low Requirements for Sequence Identity in RecombinationAIDS Research and Human Retroviruses, 2000
- An HIV Type 1 Subtype A Outbreak among Injecting Drug Users in LatviaAIDS Research and Human Retroviruses, 1999
- Circulation of Subtype A and gagA/envB Recombinant HIV Type 1 Strains among Injecting Drug Users in St. Petersburg, Russia, Correlates with Geographical Origin of InfectionsAIDS Research and Human Retroviruses, 1999
- HIV-1 genetic subtype A/B recombinant strain causing an explosive epidemic in injecting drug users in KaliningradAIDS, 1998
- Sequence Note: Extreme Founder Effect in an HIV Type 1 Subtype A Epidemic among Drug Users in Svetlogorsk, BelarusAIDS Research and Human Retroviruses, 1998
- Molecular Epidemiology of an HIV-1 Subtype A Subcluster among Injection Drug Users in the Southern UkraineAIDS Research and Human Retroviruses, 1998
- A Sudden Epidemic of HIV Type 1 among Injecting Drug Users in the Former Soviet Union: Identification of Subtype A, Subtype B, and NovelgagA/envB RecombinantsAIDS Research and Human Retroviruses, 1998
- Patterns of Amino Acid Variability in NSI-like and SI-like V3 Sequences and a Linked Change in the CD4-Binding Domain of the HIV-1 Env ProteinVirology, 1997