Design of chelate ring-opening platinum anticancer complexes: reversible binding to guanine
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 15,p. 1785-1786
- https://doi.org/10.1039/cc9960001785
Abstract
Chelate ring-opening in bis(aminophosphine) complexes of platinum(II) can be controlled by the substituents on N and P under biologically relevant conditions of pH and Cl– concentration; selective and reversible binding to the DNA base guanine can be achieved as well as cytotoxicity towards cancer cell lines.Keywords
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