CONTROL OF CORONARY BLOOD FLOW IN THE HEART-LUNG PREPARATION

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Abstract
In the heart-lung prep. the influence of various factors on coronary flow was studied with the thermostromuhr. In agreement with others an intimate dependence of coronary flow on mean arterial blood pressure was found. Changes in cardiac output had no effect on coronary flow, if the arterial pressure and the temp. of the perfusing medium were kept constant. Stimulation of the cardiac branches of the stellate ganglion of the heart-lung prep. augmented coronary flow on an avg. of about 150%. Similar values for coronary flow were obtained in the presence of a constant arterial blood pressure. The increase in coronary flow resulting from stimulation of the sympathetic nerves of the heart-lung prep. is thought to be due at least in part to a vasodilator action of the sympathetic nerves. An augmentation of coronary flow was demonstrated with acceleration of the heart rate by means of an electric stimulator. The augmented coronary flow was not due to an elevated mean blood pressure.

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