The Anti‐Parasitic Effects of Nitric Oxide

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Abstract
Endogenous and exogenous nitric oxide (NO) possesses anti‐parasitic effects on both Protozoa and Metazoa. However, NO production requires a tight control to limit cytotoxic damage to the host's own cells. The best known parasitic macromolecular targets for NO(‐donors) are cysteine proteases, which are relevant in several aspects of the parasite life cycle and parasite‐host relationships, and appear as promising targets for anti‐parasitic chemotherapy. IUBMB Life, 55: 573‐578, 2003

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