New cephalosporins cefotaxime, cefpimizole, BMY 28142, and HR 810 in experimental pneumococcal meningitis in rabbits
- 1 March 1985
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 27 (3) , 340-342
- https://doi.org/10.1128/aac.27.3.340
Abstract
Four new cephalosporins, cefotaxime, cefpimizole (U 63196E), BMY 28142, and HR 810 were evaluated in experimental pneumococcal meningitis. Cefotaxime penetrated only moderately into the cerebrospinal fluid of rabbits with meningitis, whereas cefpimizole, BMY 28142, and HR 810 all exhibited unusually good penetration. The bactericidal activity in infected cerebrospinal fluid was comparable for the four drugs.This publication has 10 references indexed in Scilit:
- Antibacterial Activity of -Lactam Antibiotics in Experimental Meningitis Due to Streptococcus pneumoniaeThe Journal of Infectious Diseases, 1984
- Bactericidal versus Bacteriostatic Antibiotic Therapy of Experimental Pneumococcal Meningitis in RabbitsJournal of Clinical Investigation, 1983
- Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli meningitisAntimicrobial Agents and Chemotherapy, 1983
- Comparison of cefoperazone with penicillin, ampicillin, gentamicin, and chloramphenicol in the therapy of experimental meningitisAntimicrobial Agents and Chemotherapy, 1982
- Pharmacokinetics and bacteriological efficacy of cefoperazone, ceftriaxone, and moxalactam in experimental Streptococcus pneumoniae and Haemophilus influenzae meningitisAntimicrobial Agents and Chemotherapy, 1982
- Antibiotic therapy of bacterial meningitis: Lessons we've learnedThe American Journal of Medicine, 1981
- Factors influencing the penetration and activity of antibiotics in experimental meningitisJournal of Infection, 1981
- Cephalosporin Antibiotics in Therapy of Experimental Streptococcus pneumoniae and Haemophilus influenzae Meningitis in RabbitsThe Journal of Infectious Diseases, 1978
- Effect of Probenecid on Cerebrospinal Fluid Concentrations of Penicillin and Cephalosporin DerivativesAntimicrobial Agents and Chemotherapy, 1974