Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure

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Abstract
Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1·26(0·19), 1·33(0·26), 1·04(0·14) and 0·86(0·13) nmol superoxide per min per 1·3 × 106 neutrophils respectively (PPPPP<0·05). These data suggest that after trauma the mediators PAF and IL‐8 appear sequentially in the circulation, are potential mechanisms of circulating neutrophil priming, and that IL‐8 may also be an early biochemical marker predicting the onset of MOF.
Funding Information
  • National Institutes of Health (P50GM49222-0, T32GMO8315)