ASSOCIATION OF LACTOFERRIN WITH SPECIFIC GRANULES IN RABBIT HETEROPHIL LEUKOCYTES

Open Access

1 March 1970

journal article
Published by Rockefeller University Press in The Journal of Experimental Medicine

Vol. 131 (3) , 559-570
https://doi.org/10.1084/jem.131.3.559

Abstract

Lactoferrin has been identified in rabbit heterophil leukocytes on the basis of its immunological reactivity, electrophoretic mobility, acid-resistant iron-binding properties, and spectral characteristics. Leukocyte lactoferrin was found to be exclusively localized in the specific (secondary) granules, which have been resolved from other subcellular components by zonal differential centrifugation and by isopycnic equilibration.

Keywords

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