Adjuvante Chemotherapie des osteogenen Sarkoms mit High-Dose Methotrexat/Leucovorin: Biochemische Effekte auf die DNA-Synthese der Knochenmarkzellen

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Abstract
DNA metabolism in bone marrow cells was measured under highdose Methotrexate/Leucovorin adjuvant chemotherapy of a patient with primary amputation of his right leg because of osteogenic sarcoma. The biochemical data showed that there was no rescue effect of Leucovorin after 200 mg/ kg Methotrexate. Corresponding to this “biochemical failure” of the rescue effect the patient died from the complications of a long and very severe bone marrow suppression. To improve the safety of this therapeutic regimen theintravenous injection and in some cases a higher dose of Leucovorin is recommended.