Structure‐function activity of azasterols and nitrogen‐containing steroids

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Abstract
Thirty-nine nitrogen-containing steroids were tested against two gramnegative, five gram-positive, and two yeast organisms. Many of these steroids have been preiously reported to inhibit various metabolism processes involving sterol metabolism. While low minimal inhibitory concentration (MIC) values were recorded for sterol producing yeast, growth of bacteria which contain no sterols was also inhibited. Structure-function studies provided no relationship between biological activitity and hypocholesteremic effects of these azasteroids. A hypothesis put forward is that amino and azasteroids are effectors of membrane which, in the case of mitochondria, lead to changes in adenosine triphosphate levels and/or dehydrogenase activity. Their effects on sterol metabolism, there-fore, may be of secondary consideration.

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