Role of Casein in Casein-Induced Amyloidosis of Mice

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Abstract
The present study of casein-induced amyloidosis of mice was intended to determine if there is any relation between the deposition of injected casein in the mouse spleen and sites of amyloid formation in the spleen. Using the technique of autoradiography, evidence was obtained that, throughout much of the course of amyloid induction, at least a portion of the injected casein was undergoing follicular localization, with initial trapping at the outer portions of the marginal zones and final localization about the germinal centers. Additional evidence for formation of antibodies to casein in this experimental model was obtained by the procedure of radioimmunoe.lectrophoresis. When amyloid formation had occurred, injected casein was shown to have prompt and ready access to it. The areas in which amyloid formation occurred corresponded to areas previously occupied by the marginal zones. The very rapid entry of the casein into the amyloid suggested increased vascular permeability. The various possible ways in which these findings might relate to amyloid formation were considered.

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