Comparison of the delayed neurotoxicity ofO‐methyl andO‐ethyl analogs of EPN, leptophos, and cyanofenphos
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Journal of Environmental Science and Health, Part B
- Vol. 17 (6) , 611-633
- https://doi.org/10.1080/03601238209372346
Abstract
Eight pairs of O‐methyl and O‐ethyl O‐(substituted‐phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. O‐methyl compounds were in all cases more active than their O‐ethyl analogs. The neurotoxic potential of the O‐methyl phenylphosphonothionates was 2,5‐diCl >4‐NO2 >2,4,5‐triCl and 2,4,6‐triCl >2,4‐diCl >2,5‐diCl‐4‐Br >4‐CN, when single oral doses were given. Both EPN‐ethyl and leptophos‐raethyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established.Keywords
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