MONOCLONAL-ANTIBODIES TO HUMAN-LEUKOCYTE ANTIGENS IN POLYMYOSITIS AND MUSCULAR-DYSTROPHY

  • 1 January 1983
    • journal article
    • research article
    • Vol. 54  (2) , 327-336
Abstract
Biopsy specimens from patients with treated or untreated polymyositis and muscular dystrophy controls were examined by indirect immunoperoxidase staining with a panel of monoclonal antibodies to human leukocyte antigens. In untreated polymyositis, helper/inducer T cells were the predominant T cell subset. In treated cases few T cells were seen. Few T cells were seen in dystrophic cases, most infiltrating cells being dendritic and lacking T cell antigens. Staining of sarcolemma with anti-HLA class 1 antibody is weak or negative except in areas adjacent to infiltrating leucocytes or where muscle fiber damage is apparent.