Cell adhesion to substrates containing adsorbed or attached IgG.

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Abstract
When most mammalian cells are propagated in tissue culture, they are attached to a solid surface. This surface is commonly covered with a layer of serum protein. The effect of the protein layer on the interaction between the cells and the surface was studied by precoating the surface with various pure protein molecules. No differences between surfaces covered with pure protein layers and those covered with serum proteins were found except when antibody molecules were used. In all cases the cell types used avoided surfaces covered with antibody molecules. Previously, other investigators have established that some cells belonging to the immunology system are attracted to such surfaces. [Rat heart, lung, kidney and tumor cells were used in these experiments.].