MECHANISMS OF INHIBITION BY SIMULTANEOUSLY ADMINISTERED PHENOBARBITAL OF 3'-METHYL-4-(DIMETHYLAMINO)AZOBENZENE-INDUCED HEPATOCARCINOGENESIS IN THE RAT
- 1 January 1980
- journal article
- research article
- Vol. 71 (6) , 755-758
Abstract
The mechanisms of inhibition by simultaneously administered phenobarbital of 3''-methyl-4-(dimethylamino)azobenzene (3''-Me-DAB)-induced hepatocarcinogenesis in the rat were studied. Weanling rats were fed a diet containing 0.06% 3''-Me-DAB or 0.06% 3''-Me-DAB and 0.05% phenobarbital for 3 wk, followed by a basal diet or a diet containing 0.05% phenobarbital as a promoter. The number and the size of enzyme-altered islands and the number of tumors larger than 5 mm in diameter were scored at 12 and 40 wk, respectively. The simultaneous feeding of phenobarbital and 3''-Me-DAB resulted in a significant decrease in the number and size of enzyme-altered islands and in the number of tumors, in comparison with those scored in animals fed 3''-Me-DAB alone. The simultaneous feeding of phenobarbital apparently inhibits the initiation of carcinogenesis and the promotive action of the carcinogen resulting from its selective toxicity on the liver tissue.This publication has 4 references indexed in Scilit:
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