MULTIPLE SERUM PROTEIN DEFICIENCIES IN CONGENITAL AND ACQUIRED AGAMMAGLOBULINEMIA 1

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Abstract
Antigenic analysis of sera from 8 patients with congenital agammaglobulinemia, 3 patients with the acquired form of the disease and 6 normal adults, was performed, using rabbit and horse antisera. The rabbit and horse antisera against human gamma-globulin contained antibodies against other plasma antigens besides gamma-globulin. The immunoelectrophoresis method of analysis in agar was used. Through use of agar diffusion and electrophoretic methods, it has been demonstrated that at least 2 plasma proteins besides gamma-globulin are absent or deficient in agammaglobulinemia; these proteins migrate as beta-globulins in agar. It is confirmed that the deficiency of gamma-globulin in agammaglobulinemia is often not complete.