A Molecular Whodunit
- 7 September 2001
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5536) , 1773-1775
- https://doi.org/10.1126/science.1065206
Abstract
The Spanish flu pandemic killed more than 20 million people worldwide in 1918. An extremely virulent influenza virus that jumped from chickens to humans appeared in Hong Kong in 1997. Why is it that these particular flu viruses were so virulent? In an enlightening Perspective, Webster discusses new work ( Hatta et al., Gibbs et al.) that offers fresh insights into the factors determining flu virus virulence. In addition, he advises on the steps that we need to take to avert another flu pandemic on the scale of the Spanish flu.This publication has 15 references indexed in Scilit:
- Recombination in the Hemagglutinin Gene of the 1918 "Spanish Flu"Science, 2001
- Molecular Basis for High Virulence of Hong Kong H5N1 Influenza A VirusesScience, 2001
- Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genesProceedings of the National Academy of Sciences, 2001
- Influenza A pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiologyReviews in Medical Virology, 2000
- Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient SystemsVirology, 1998
- Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteinsJournal of Virology, 1991
- Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine virusesJournal of Virology, 1991
- Amplification, expression, and packaging of a foreign gene by influenza virusCell, 1989
- Laboratory characterization of a swine influenza virus isolated from a fatal case of human influenzaJournal of Clinical Microbiology, 1989
- Attenuation of pathogenicity of fowl plague virus by recombination with other influenza A viruses nonpathogenic for fowl: nonexculsive dependence of pathogenicity on hemagglutinin and neuraminidase of the virusJournal of Virology, 1976