Cytological detection of mutagen–carcinogen exposure by sister chromatid exchange
- 1 November 1975
- journal article
- Published by Springer Nature in Nature
- Vol. 258 (5531) , 121-125
- https://doi.org/10.1038/258121a0
Abstract
A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens-carcinogens. The test gives a very sensitive and rapid method for detecting chromosome mutagenicity of chemical agents and provides a powerful new method for detecting environmental mutagens.Keywords
This publication has 29 references indexed in Scilit:
- Sister chromatid exchange in human chromosomes from normal individuals and patients with ataxia telangiectasiaCytogenetic and Genome Research, 1975
- New Giemsa method for the differential staining of sister chromatidsNature, 1974
- Sister chromatid exchanges induced by light flashes to 5-bromodeoxyuridine- and 5-iododeoxyuridine substituted Chinese hamster chromosomesExperimental Cell Research, 1974
- UV-induced chromatid aberrations in cultured Chinese hamster cells after one, two, or three rounds of DNA replicationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
- Photoreactivation of Ultraviolet-Induced Chromosomal AberrationsScience, 1973
- Induction of sister chromatid exchanges in chromosomes of rat kangaroo cells by tritium incorporated into DNAExperimental Cell Research, 1972
- DNA repair and chromatid anomalies in mammalian cells exposed to 4-nitroquinoline 1-oxideMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1970
- The induction of chromosome aberrations by nitrogen mustard and its dependence on DNA synthesisProceedings of the Royal Society of London. B. Biological Sciences, 1969
- THE FREQUENCY OF SISTER CHROMATID EXCHANGES FOLLOWING EXPOSURE TO VARYING DOSES OF H3-THYMIDINE OR X-RAYSThe Journal of cell biology, 1964
- FACTORS AFFECTING THE PRODUCTION OF CHROMOSOME ABERRATIONS BY CHEMICALSThe Journal of cell biology, 1956