Powder mixing in the tableting of fenfluramine hydrochloride; evaluation of a mixer

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Abstract
A vertical cone mixer has been used to mix a single active component, fenfluramine hydrochloride, with a number of diluents used for production batch-scale tablet preparation. The mixing operation was followed by the analysis of fenfluramine hydrochloride in a number of samples equivalent to the final tablet size. The results may be suitably analysed by treating the diluent materials as a single component in a binary mixture.