Synthesis of α-Hydroxycarboxamides from Acetonides of α-Hydroxycarboxylic Acids and Primary Amines
- 1 January 1985
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1985 (12) , 1153-1155
- https://doi.org/10.1055/s-1985-31460
Abstract
The reaction of acetonides of α-hydroxycarboxylic acids with primary amines on heating provides a useful synthetic route to N-substituted α-hydroxycarboxamides. In general, formation of the α-hydroxycarboxamides is favored by the presence of only small substituents on the acetonide, by sufficient nucleophilicity of the amine, and by high-boiling aprotic solvents.Keywords
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