THE EFFECT OF THE DAILY ADMINISTRATION OF IODINE ON THE CALORIGENIC ACTION OF SINGLE INTRAVENOUS INJECTIONS OF THYROXINE

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Abstract
The experiments were performed on a [female] dog on which bilateral oophorectomy had been performed 2 yrs. previously and accustomed for 2 yrs. to experimental procedures. A series of 13 to 15 tests was carried out each experimental day; the average results represented the day''s metabolism. In 3 control experiments 10 mgm. of thyroxine were given for 190 hrs. without I; in 2 experiments I was givefter the administration of thyroxine. The daily oral administration of I for 17 and 22 days before and for 8 days after a single intravenous injection of 10 mgm. of thyroxine did not influence the calorigenic action of thyroxine. Following the injection of thyroxine the basal heat production rose rapidly and reached its maximal height in from 22 to 70 hrs.; following this there was a progressive decrease in heat production which reached the original basal level in about 8 days. In the 3 control experiments in which I was not given the extra heat production averaged 300 calories; in 2 experiments in which I was given the average was 311 calories. The response of the same animal to repeated single injections of 10 mgm. of thyroxine was constant; the average extra heat production in 5 experiments amounted to 304 calories, and the maximal and minimal-values obtained were within [long dash] 8% of this average. The daily oral administration of I was without appreciable influence on the basal level of heat production.