Central and Peripheral Action of Enkephalin Analogues

1 January 1983

journal article
research article
Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie

Vol. 364 (2) , 1555-1562
https://doi.org/10.1515/bchm2.1983.364.2.1555

Abstract

Chemical modifications of enkephalins led to analogues with strongly increased biological potency. Compounds such as H-Tyr-DLys(CHO)-Gly-Phe-L-homocysteinethiolactone (Hoe 825) additionally show a remarkable split between central and peripheral action, favouring the stimulation of gastrointestinal contractions. Hoe 825 could, therefore, be useful in the treatment of conditions where gut motility is lacking in humans, especially in adynamic ileus.

Keywords

TREATMENT
STIMULATION
GUT
ENKEPHALIN
ANALOGUES
ILEUS
GLY
CONTRACTIONS
PERIPHERAL ACTION

This publication has 1 reference indexed in Scilit:

Effects of the synthetic enkephalin analogue FK 33-824 in man
Nature, 1978