Diatrizoate Distribution in Dogs as a Function of Administration Rate and Time Following Intravenous Injection

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Abstract
Diatrizoate concentrations in plasma and the extravascular space in dogs were determined following an injection of the same dose of diatrizoate under 3 different conditions: (A) subsequent to a rapid bolus injection of diatrizoate; (B) subsequent to a bolus injection followed by an i.v. drip infusion and (C) subsequent to a slow i.v. drip infusion. The highest plasma level occurred immediately after bolus injection (A). Significantly more diatrizoate was present in plasma 10-25 min from the start of an i.v. drip infusion given over 12.5 min (C) than when the same dose was given as a rapid bolus (A). The slow infusion method also resulted in significantly higher diatrizoate plasma levels from 15-25 min when compared to the bolus plus drip method (B). The differences in the calculated extravascular concentrations were insignificant among the 3 groups once all of the contrast material was infused, i.e., after 12.5 min. The results are discussed in terms of their practical application to cranial computed tomography.

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