Hippocampal benzodiazepine receptors in schizophrenia
- 1 June 1993
- journal article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 93 (2) , 151-155
- https://doi.org/10.1007/bf01245344
Abstract
Benzodiazepine receptor sites were determined by saturable [3H]flunitrazepam binding in hippocampal tissue from schizophrenic and control subjects. No difference in receptor density or affinity between the two groups was observed, indicating that the previously identified GABAergic deficit in the hippocampus in schizophrenia does not apparently lead to up-regulation of these receptor sites. The implications of this finding are discussed.Keywords
This publication has 19 references indexed in Scilit:
- Benzodiazepines in the treatment of schizophrenia: an updated surveyActa Psychiatrica Scandinavica, 1991
- [3H]Nipecotic Acid Binding to γ‐Aminobutyric Acid Uptake Sites in Postmortem Human BrainJournal of Neurochemistry, 1990
- Schizophrenia: the cellular biology of a functional psychosisTrends in Neurosciences, 1990
- Dementia in Huntington's disease is associated with neurochemical deficits in the caudate nucleus, not the cerebral cortexNeuroscience Letters, 1990
- Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophreniaBiological Psychiatry, 1990
- Reduced GABA uptake sites in the temporal lobe in schizophreniaNeuroscience Letters, 1989
- Benzodiazepine receptors increase in post-mortem brain of chronic schizophrenicsArchiv Fur Psychiatrie Und Nervenkrankheiten, 1989
- Neurochemical characteristics of early and late onset types of Alzheimer's disease.BMJ, 1984
- Increased concentrations and lateral asymmetry of amygdala dopamine in schizophreniaNature, 1983
- Hippocampal influence on amygdala unit activity in awake squirrel monkeysBrain Research, 1980