The Influence of Neighboring Base Pairs upon Base-Pair Substitution Mutation Rates
- 1 April 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (4) , 773-776
- https://doi.org/10.1073/pnas.68.4.773
Abstract
The 2-aminopurine-induced transition, A.T --> G.C, was studied at particular sites in bacteriophage T4 as a function of the nearby base-pair composition of the DNA. Changing a base pair changed the transition rate at the adjacent base pair up to 23-fold, and at the next base pair by a lesser amount. Destabilization was achieved by replacing an A.T base pair by a G.C base pair.Keywords
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